agilent 6460c triple quad lcms with 1260 hplc

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Agilent 6460C Triple Quadrupole LC/MS System with 1260 Infinity HPLC

The Agilent 6460C Triple Quadrupole LC/MS System, paired with the Agilent 1260 Infinity HPLC, represents a state-of-the-art solution for high-sensitivity quantitative analysis in a wide range of applications including pharmaceutical, environmental, food safety, forensics, and clinical research. This fully integrated system combines ultra-reliable liquid chromatography (LC) with robust triple quadrupole mass spectrometry (MS/MS), delivering exceptional performance in targeted compound quantification and complex matrix analysis.

Key Features:

Agilent 6460C Triple Quadrupole Mass Spectrometer:

• Triple Quadrupole MS/MS System with high-speed MRM capability

• iFunnel Technology for improved ion sampling and transmission

• Agilent Jet Stream ESI Source: Increases signal-to-noise for better sensitivity

• Polarity Switching in <20 ms for simultaneous positive/negative ion detection

• Dynamic MRM (dMRM): Enables higher throughput and efficient quantitation of hundreds of analytes

• Low Detection Limits: Sub-picogram or ppb-level detection in complex matrices

• Fast Scan Speeds: Supports high-resolution chromatography

• Thermal Management System for consistent performance and reliability

Agilent 1260 Infinity HPLC:

• Quaternary or Binary Pump Configurations

• Flexible Injector Options: Autosampler, manual injector, or preparative systems

• Thermostatted Column Compartment for precise temperature control

• UV/Vis DAD, FLD, or RID Detectors (optional, depending on configuration)

• High-Pressure Tolerance: Up to 600 bar for high-resolution columns

• Easy Maintenance and Modular Design

Applications:

• Pharmaceutical Analysis: Bioanalysis, drug metabolism and pharmacokinetics (DMPK), impurity profiling

• Clinical Research: Quantitative proteomics, metabolomics, therapeutic drug monitoring

• Food Safety: Pesticide residues, mycotoxins, veterinary drugs

• Environmental Testing: Water pollutants, persistent organic pollutants (POPs), endocrine disruptors

• Forensics and Toxicology: Drug screening, toxic compound quantification

• Biochemical and Molecular Biology Research

Benefits:

• Superior Sensitivity and Dynamic Range for low-level analyte detection

• High Throughput Capabilities with dynamic MRM and rapid scan times

• Enhanced Method Development Tools and intuitive MassHunter software suite

• Consistent Performance Across Laboratories for regulated environments

• Scalable and Flexible System Architecture for future upgrades

• Trusted Agilent Reliability and global support

Technical Specifications (6460C Triple Quad):

• Mass Range: m/z 5–3,000

• Scan Modes: MRM, full scan, product ion, precursor ion, neutral loss

• Polarity Switching Time: <20 ms

• Sensitivity (ESI): Attogram to femtogram-level LLOQ (analyte dependent)

• Ion Source Options: ESI, APCI, multimode, Jet Stream

• Data System: Agilent MassHunter Workstation

• Vacuum System: Split-flow turbo molecular pump

Technical Specifications (1260 Infinity HPLC):

• Pressure Rating: Up to 600 bar

• Flow Rate Range: 0.001 to 5 mL/min (depending on pump type)

• Injection Volume: Typically 1–100 µL (autosampler dependent)

• Column Temperature Range: Ambient to 80°C

• Detector Options: DAD, VWD, FLD, RID

The Agilent 6460C LC/MS system with 1260 HPLC is the preferred choice for analytical scientists seeking ultra-sensitive, accurate, and reproducible quantitation in complex sample matrices. Its robust design, intelligent software, and superior ion handling make it an ideal platform for both regulated environments and exploratory research, delivering confidence in every result.